She began her career as a teenager winning the biggest singing competition for juniors on Danish National Television. This music phenomenon garnered both a Gold Certified album and received a Danish Music Award as a teen before embarking upon a very successful international modeling career. This modeling venture afforded Sisse the opportunity to work in Milan, London, Munich, Atlanta, Istanbul, Copenhagen, Stockholm and beyond. While still modeling she also released a top 5 single and hosted the most watched show on Danish MTV.
- On 15 November 2012, Sisse Marie had her song "Paralyzed" featured in the best selling video game of all time The Sims.